Registration Dossier
Registration Dossier
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EC number: 220-260-0 | CAS number: 2691-41-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
HMX toxicokinetic, metabolism and distribution assessment is based on the data from toxicokinetics studies following single oral and intravenous administrations (Cameron, 1986), acute oral and dermal studies (Cuthbert et al., 1985) , in vitro skin absorption study (Reifenrath, 2002), and subacute and subchronic repeat dose studies (Everett et al., 1985; Everett and Maddock., 1985) . These studies suggest that HMX is poorly absorbed via the oral and dermal routes. Most of an orally administered dose of HMX is excreted in the faeces as unchanged HMX within 96h. The small amount of HMX that is absorbed in the body may be temporarily found, particularly in the plasma, lungs, liver, heart, and kidneys. However, the levels of HMX in these tissues do not remain elevated for very long. Data indicate that HMX is readily metabolised to polar intermediates; however, these metabolites have not been identified. Most of an absorbed dose of HMX is excreted in the urine within 4 days.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 5
- Absorption rate - dermal (%):
- 4
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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