Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-323-3
CAS number: 908020-52-0
[1,1,2,2-tetrafluoro-2-(pentafluoro-ethoxy)] ethoxy acetic acid (EEA) in
the vehicle, sterile water for injection, was administered intravenously
once to 1 pharmacokintic (blood collection) and 1 excretion group of
Crl:CD(SD) rats (WIL Research Laboratories, LCC, 2007). The dosage level
was 10 mg/kg bw for both groups at a dosage volume of 5 mL/kg. The
pharmacokinetic group consisted of 9 animals/sex and the excretion group
consisted of 3 animals/sex.
Systemic exposure (AUC0-∞) to EEA for male
rats was almost 7-fold higher than for female rats following a single
intravenous dose of EEA at 10 mg/kg bw. EEA in the serum cleared more
rapidly in the male rats than in the female rats, and the female rats
had a greater volume distribution than the male rats. EEA cleared in the
urine more rapidly in the female rats than in the male rats, but most of
the EEA dose was eliminated over 12 hours post-dosing in both genders.
The elimination of EEA in the urine appeared to be mono-exponential for
male rats and appeared not to be log-linear for female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
За да гарантираме, че се възползвате максимално от функциите на нашия уебсайт, сме въвели „бисквитки“.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again