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EC number: 700-323-3
CAS number: 908020-52-0
[1,1,2,2-tetrafluoro-2-(pentafluoro-ethoxy)] ethoxy acetic acid (EEA) in
the vehicle, sterile water for injection, was administered intravenously
once to 1 pharmacokintic (blood collection) and 1 excretion group of
Crl:CD(SD) rats (WIL Research Laboratories, LCC, 2007). The dosage level
was 10 mg/kg bw for both groups at a dosage volume of 5 mL/kg. The
pharmacokinetic group consisted of 9 animals/sex and the excretion group
consisted of 3 animals/sex.
Systemic exposure (AUC0-∞) to EEA for male
rats was almost 7-fold higher than for female rats following a single
intravenous dose of EEA at 10 mg/kg bw. EEA in the serum cleared more
rapidly in the male rats than in the female rats, and the female rats
had a greater volume distribution than the male rats. EEA cleared in the
urine more rapidly in the female rats than in the male rats, but most of
the EEA dose was eliminated over 12 hours post-dosing in both genders.
The elimination of EEA in the urine appeared to be mono-exponential for
male rats and appeared not to be log-linear for female rats.
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