2,6-dichlorobenzaldehyde

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: DIN 38 412-1,11 (1982)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,6-dichlorobenzaldehyde

EC Number:

201-472-2

EC Name:

2,6-dichlorobenzaldehyde

Cas Number:

83-38-5

Molecular formula:

C7H4Cl2O

IUPAC Name:

2,6-dichlorobenzaldehyde

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Test conditions

Nominal and measured concentrations:

2.9-21.5 mg/l

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

>= 8.2 - <= 11.57 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other:

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

2,6-Dichlorobenzaldehyde is toxic to Daphnia Magna Strauss.

Executive summary:

The observation period was 24 hours. Current test methods require observation over 48 hours. In the case of repetition according to the new test regulations, the result of the EC50 could therefore be a few mg / l lower. With a possible influence on the result, the almost tenfold excess of the test sample weight for the production of the saturated solution must also be assessed. Since 2,6-dichlorobenzaldehyde as a chemical is usually of high purity, the deviation of the result due to this approach is to be assessed as minor. The result of the EC50 of this test is at the upper end of the evaluation range from 1 to 10 mg / l for the statement "toxic to the test organisms". Therefore, even if carried out according to the current method and with only a slight excess in the preparation of the saturated solution, an evaluation as "very toxic" would not be expected. The EC50 would have to be lower by a factor of about 8 to 10 (<= 1 mg / l). On the other hand, a more favorable evaluation when the test is repeated is also extremely unlikely because of the longer test duration. Other differences between the earlier methods and today's methods, such as changes in the mineral content of the dilution water, have no significant influence on the test result.

The validity of the present test result is graded down due to the deviations from the current procedure presented here and due to the small volume of the archived laboratory records, on the other hand, taking into account the discussion in the previous paragraph and the general status of the presentation in the year the test was carried out, it is still sufficient for general risk assessments judged.

Für das Ergebnis der Toxizitätsprüfung von 2,6-Dichlorbenzaldehyd im Daphnien-Kurzzeittest wurde die folgende Bewertung abgegeben:

2,6-Dichlorbenzaldehyd ist giftig gegenüber Daphnia magna STRAUSS; Wasserfloh. Die EC50 liegt im Bewertungsbereich >l mg/l bis 10 mg/l.

The following rating was given for the result of the toxicity test of 2,6-dichlorobenzaldehyde in the daphnia short-term test: 2,6-dichlorobenzaldehyde is toxic to Daphnia magna STRAUSS; Water flea.

The EC50 is in the evaluation range > 1 mg / l to 10 mg / l.