Registration Dossier
Registration Dossier
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EC number: 201-472-2 | CAS number: 83-38-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Non-GLP-Test. The exposure time is 24 hours and therefore very long. It is not judged whether the very long contact time inadmissibly falsifies the results. The assessment of the results is inconclusive; in particular, there is no justification for why the result after 8d (end of observation period) is not taken into account. Observations after 48 h are not reported. With a more conservative evaluation, the study can nevertheless be used for risk assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR Title 16, Section 1500.41
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6-dichlorobenzaldehyde
- EC Number:
- 201-472-2
- EC Name:
- 2,6-dichlorobenzaldehyde
- Cas Number:
- 83-38-5
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 2,6-dichlorobenzaldehyde
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 8 d
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- 48 h
- Remarks on result:
- other: Not reported
- Irritation parameter:
- edema score
- Time point:
- 48 h
- Remarks on result:
- other: Not reported
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The exposure time of 24 h is significant longer then according to OECD standard methods. Therefore values after 4 h are not available. Because of the uncertainties of these study the substance is classified as corrosive instead of severly irritating.
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