Registration Dossier
Registration Dossier
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EC number: 201-472-2 | CAS number: 83-38-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR Title 16, Section 1500.42
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6-dichlorobenzaldehyde
- EC Number:
- 201-472-2
- EC Name:
- 2,6-dichlorobenzaldehyde
- Cas Number:
- 83-38-5
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 2,6-dichlorobenzaldehyde
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 µl
- Duration of treatment / exposure:
- 8d
- Observation period (in vivo):
- 8d
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 8.3
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 4.2
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.67
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 4.2
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 4.2
- Max. score:
- 10
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 3.33
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 8d
- Score:
- 1.67
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 14.3
- Max. score:
- 20
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 13.67
- Max. score:
- 20
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 10.67
- Max. score:
- 20
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 8d
- Score:
- 0.67
- Max. score:
- 20
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Included in overall evaluation of conjunctivae
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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