Octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-01-29 to 2018-06-14

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD 105

GLP compliance:

no

Key result

Medium:

n-octanol

Solubility:

88.67 g/L

Temp.:

19.9 °C

Test substance stable:

yes

Details on results:

The measured concentration of the test substance did not change with increasing dissolution duration in the climatic exposure test cabinet at 30°C (<15%; Table 2; Figure 1-4).
The highest measured concentration was 92.10 g/L after 48 h dissolution at 30°C. The change between the 48-h and 72-h sample was <6%.
The average dissolved concentration of test substance in n-octanol was 88.67 mg/L.

Conclusions:

The flask method revealed a n-octanol solubility for octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine of n-octanol solubility: 88.67±2.44 g/L (at 19.9°C and pH 5-6)

Executive summary:

The n-octanol solubility of octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine was determined according to the flask method described in the OECD Guideline 105 (1995) using n-octanol instead of water. Therefore, the test substance was shaken in n-octanol at 30°C (for 24, 48 and 72 h) and equilibrated afterwards at 20°C for further 24 h.

The obtained samples were measured using HPLC. The n-octanol solubility of octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine was determined to be: n-octanol solubility: 88.67±2.44 g/L (at 19.9°C and pH 5-6)

Description of key information

The solubility for octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine in n-octanol solubility is 88.67±2.44 g/L (at 19.9°C and pH 5-6)

Key value for chemical safety assessment

At the temperature of:

19.9 °C

Solubility in organic solvents at 20°C:

88.67 g/L

Additional information

The n-octanol solubility of octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine was determined according to the flask method described in the OECD Guideline 105 (1995) using n-octanol instead of water. Therefore, the test substance was shaken in n-octanol at 30°C (for 24, 48 and 72 h) and equilibrated afterwards at 20°C for further 24 h.

The obtained samples were measured using HPLC. The n-octanol solubility of octadecanoic acid, reaction products with acetic acid and tetraethylenepentamine was determined to be: n-octanol solubility: 88.67±2.44 g/L (at 19.9°C and pH 5-6)