Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31 August 2017 - 05 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Key result
Water solubility:
1.08 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
5 - 6
Details on results:
According to the test guideline five consecutive samples should not differ in concentration by more than ±30 % and the mean values obtained from two tests with different flows should not differ by more than 30 %. These criteria were fulfilled and therefore, the study is valid.

Table 1. Results for the determination of water solubility

 Test number  Flow rate (mL/h)  Water solubility (mg/L)
 1  41  1.11
 1  41  0.888
 1  41  1.19
 1  41  1.14
 1  41  1.02
 Average of test 1  41  1.07 ± 0.12
 2  21  0.909
 2  21  1.17
 2  21  0.895
 2  21  1.15
 2  21  1.30
 Average of test 2  21  1.09 ± 0.18
 Average of tests 1 and 2  -  1.08 ± 0.15
Conclusions:
The water solubility of the test item was found to be 1.08 ± 0.15 mg/L at 20 °C.
Executive summary:

The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6). The study was conducted according to OECD Method 105 and was GLP-compliant, therefore it is considered to be reliable without restriction (Klimisch 1).

Description of key information

The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6).

Key value for chemical safety assessment

Water solubility:
1.08 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6) (2017). The study was conducted according to OECD Method 105 and was GLP-compliant, therefore it is considered to be reliable without restriction (Klimisch 1).