Registration Dossier
Registration Dossier
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EC number: 212-379-1 | CAS number: 812-00-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
The NOAEL for maternal toxicity was considered to be 120 mg/kg bw/day for a similar multi-constituent substance. In combination with severe maternal toxicity observed at 450 mg/kg bw/d an increase in pup loss at birth and a decreased litter weight was noted in the high dose group. These developmental effects are considered to be caused by the maternal toxicity at 450 mg/kg bw/d. The developmental NOAEL is set at 120 mg/kg bw/day (OECD 422).
Effects on developmental toxicity
Description of key information
Effects reported were attributed to maternal toxicity.
Justification for classification or non-classification
Critical effects were not observed in an OECD 422 study via the oral route and classification for reproductive or developmental toxicity is not required under the terms of Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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