Registration Dossier
Registration Dossier
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EC number: 212-379-1 | CAS number: 812-00-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl dihydrogen phosphate
- EC Number:
- 212-379-1
- EC Name:
- Methyl dihydrogen phosphate
- Cas Number:
- 812-00-0
- Molecular formula:
- CH5O4P
- IUPAC Name:
- methyl dihydrogen phosphate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- albino
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin served as control
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- Three
Results and discussion
In vivo
Results
- Remarks on result:
- other: severe dermal reactions with necrosis in all three animals
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Severe dermal irritation with necrosis were reported for all three animals tested.
- Executive summary:
A single semi-occlusive application of the test item to intact rabbit skin for four hours elicited severe dermal irritation with necrosis.
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