Registration Dossier
Registration Dossier
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EC number: 212-379-1 | CAS number: 812-00-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl dihydrogen phosphate
- EC Number:
- 212-379-1
- EC Name:
- Methyl dihydrogen phosphate
- Cas Number:
- 812-00-0
- Molecular formula:
- CH5O4P
- IUPAC Name:
- methyl dihydrogen phosphate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Single dose of 2.0 g/kg bw
- No. of animals per sex per dose:
- Five males and five females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female died on study Day 2
- Clinical signs:
- other: Piloerection, abnormal body carriage (hunched posture, abnormal gait (waddling), lethargy, decreased respiratory rate, partially closed eyelids, apllor of extremities, increased salivation, noisy respiration and walking on toes. Recovery was complete by D
- Gross pathology:
- No abnormalities noted at macroscopic examination.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was found to be > 2.0 g/kg bw.
- Executive summary:
Following a single oral dose of 2.0 g/kg bw test material, the LD50 was found to be > 2.0 g/kg bw.
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