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Short term Toxicity to Fish: On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of mortality effect of test chemical on fishes the 96 hr LC50 value was determined to be > 159 to < 320 mg/l.


Short term toxicity to aquatic invertebrates: On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of immobility effect of test chemical on daphnia magna the 48 hr EC50 value was determined to be > 100 to < 400 mg/l.


Toxicity to aquatic algae: On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of toxicity to green algae the 72 hr EC50 value was determined to be > 100 mg/l.


Toxicity to microorganisms: On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism. EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l in duration of 3 hr to 16 hr.

Additional information

Short term Toxicity to Fish: 


Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:


The first includes study of short-term toxicity to fishes was carried out. The duration of study was 96 hr. Bluegill (Lepomis macrochirus) was taken as test organism. On the basis of mortality effect of test chemical on bluegill (Lepomis macrochirus) the 96 hr NOEC and LC50 value was determined to be 100 mg/l and 159 mg/l respectively. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 


The second study was of short-term toxicity to fishes was carried out. The duration of study was 96 hr. Rainbowfish (Poecilia reticulata) was taken as test organism. On the basis of mortality effect of test chemical on rainbowfish (Poecilia reticulata) the 96 hr LC50 value was determined to be 320 mg/l. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 


The third study includes short-term toxicity to fish. The duration of study was 96 hr. Fathead minnow (Pimephales promelas) was taken as test organism. On the basis of mortality effect of test chemical on fathead minnow (Pimephales promelas) the 96 hr LC50 value was determined to be 190 mg/l. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 


On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of mortality effect of test chemical on fishes the 96 hr LC50 value was determined to be > 159 to < 320 mg/l


As per the above information the test chemical was considered as not classified as per CLP criteria. 


Short term toxicity to aquatic invertebrates: 


Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on aquatic invertebrates. The studies are as mentioned below:


The first study of short-term toxicity to aquatic invertebrates was carried out. The duration of test was 48 hr performed under static conditions. Daphnia magna was taken as a test organism. On the basis of the immobility effect of test chemical on daphnia magna the 48 hr EC50 value was determined to be 113 mg/l. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria. 


The second study was of short-term toxicity to aquatic invertebrates. The duration of test was 48 hr performed under semi static conditions. Daphnia carinata was taken as a test organism. The test vessel was taken as 100 ml glass beaker.  Renewal rate of test solution was done daily. Number of organisms per vessel was taken as 12. Number of vessels per concentration (replicates) was taken as four. Test conditions includes temperature of 20 ± 1 °C, adjustment of pH 6.8-7.0 was done with 1 M NaOH and dissolved oxygen was of 6.5 mg/L. Photoperiod of 16 hr light with 8 hr darkness was provided. Test concentration includes 0, 25, 50, 100, 200, 400, 800 mg/L. Probit analysis was used to calculate the 24-h, 48 hr EC50. On the basis of mortality effect of test chemical on test organism Daphnia carinata the 24, 48 hr EC50 value was determined to be 342.9 mg/L, with 95% CI of 168.5 to 678.6 mg/l and 245.0 mg/L with 95% CI of 200 to 400 mg/l respectively.


The third study includes short-term toxicity to aquatic invertebrates was carried out. The duration of test was 48 hr performed under static conditions. Daphnia magna was taken as a test organism. On the basis of the immobility effect of test chemical on daphnia magna the 48 hr EC50 value was determined to be > 100 mg/l. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria. 


On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of immobility effect of test chemical on daphnia magna the 48 hr EC50 value was determined to be > 100 to < 400 mg/l.As per the value of EC50, the test chemical was considered as not classified as per CLP criteria. 


Toxicity to aquatic algae: 


Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on aquatic algae. The studies are as mentioned below:


First study was of toxicity to aquatic algae. Duration of study was 8 days. Microcystis aeruginosa a freshwater cyanobacteria was taken as test organism. On the basis of toxicity to freshwater cyanobacteria ( Microcystis aeruginosa) the 8 days EC0 and EC50 value was determined to be 76 mg/l and > 76 mg/l respectively. 


Second study includes of toxicity to aquatic algae study. Duration of study was 72 hr.  Selenastrum capricornutum a freshwater green algae was taken as test organism. On the basis of toxicity to green algae (Selenastrum capricornutum) the 72 hr EC50 value was determined to be > 72.7 mg/l. 


Study of toxicity to aquatic algae was carried out in accordance with OECD 201. Duration of study was 72 hr. Green algae Pseudokirchnerella subcapitata, was taken as test organism. Nominal concentrations of 60, 80, and 100 mg/l were used, during the test the concentrations were measured by HPLC. On the basis of toxicity to growth rate of green algae Pseudokirchnerella subcapitata, 72 hr NOEC and EC50 value was determined to be 79. 4 and > 100 mg/l respectively. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria. 


On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of toxicity to green algae the 72 hr EC50 value was determined to be > 100 mg/l. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria. 


Toxicity to microorganisms: 


Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on microorganisms. The studies are as mentioned below:


The first study includes toxicity to microorganisms was carried out. Duration of study was 16 hr. Pseudomonas putida was taken as test organisms. As per the toxicity to microorganisms study the 96 hr EC0 and EC50 value was determined to be 105 mg/l and > 105 mg/l respectively.


The second study includes study of toxicity to microorganisms was carried out in accordance with OECD 209. The duration of the study was 3 hr.  Source of test chemical was Akzo Nobel Chemicals b.v. Amersfoort. Activated sludge of predominantly domestic sewage was taken as test organism. On the basis of toxicity to microorganisms study the 3 hr EC10, EC20 and EC50 value was determined to be 48 mg/l, 105 mg/l and 403 mg/l (with 95% CI value of 227 to 597 mg/l) respectively. 


On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism. EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l in duration of 3 hr to 16 hr.