Registration Dossier
Registration Dossier
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EC number: 256-852-0 | CAS number: 50925-66-1
Endpoint summary
Administrative data
Description of key information
Since Cr(OH)Cl2 will dissociate in water or if ingested, it is considered valid to assess chloride ion and chromium ion toxicity.
In view of the wealth of information available on chromium and fluoride, no further animal testing can be justified.
Regardless of the high Cr3+ doses, chromium(III) oxide did not cause any significant treatment-related changes in the general condition of animals, body weights, clinical biochemistry, haematology, or pathological examination. The lack of toxicity of chromium(III) oxide can be explained by the poor bioavailability of this water-insoluble chromium compound. Faeces of treated animals showed an intense green discoloration, indicating significant excretion of the substance into faeces.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 0.36 mg/kg bw/day
- Study duration:
- chronic
- Species:
- other: Human studies - WHO Guidelines for Drinking-Water Quality
- Organ:
- bone
- tooth
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEC
- 44 000 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Confirmed in CICAD Review document (UN Concise International Chemical Assessment Document 76 )
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 44 000 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Confirmed in CICAD Review document (UN Concise International Chemical Assessment Document 76 )
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
