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Diss Factsheets
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EC number: 256-852-0 | CAS number: 50925-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- As with all inorganic salts, the significance for toxicity or environmental assessment is the presence of specific ions that will form when in solution or when in biological systems.In the case of Cr III salts, the counter ion will have an effect on solubility and this is itself dependant on the type of media being used and in particular the pH of that media. It is generally accepted that in the case of metal salts, testing with salts that are soluble in the respective test media will ensure maximum exposure of the metal ions. This will include chlorides and nitrates as being more soluble and will indeed have relevance when dissolved in acid media, such as if ingested.Read-across to other chromium III salts is therefore considered valid as long as the exposure in the test system is greater than would be expected for the substance under review for registration.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Principles of method if other than guideline:
- Basic principles for LC50 followed.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- No sample methods cited
- Vehicle:
- no
- Details on test solutions:
- Solutions of 0, 100, 200, 400, 800 mg/l as Chromium III sulphateEquivalent to 0, 31.5, 63, 126, 252 mg/l as Cr
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM- Common name: Cyprinus carpio (Common carp)- Length at study initiation (length definition, mean, range and SD): 4 cm - 6cmTEST ORGANISM- Common name: Aristichthys nobilis (Big head)- Length at study initiation (length definition, mean, range and SD): 4 cm - 6cm
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 10 d
- Remarks on exposure duration:
- Extended for 10 days with an abjective of performing pathology on the fish. 96 hour mortalities noted and 96 hour EC50 included in the report
- Hardness:
- 195 mg/g as Ca CO3
- Test temperature:
- Not specified
- pH:
- Not specified
- Dissolved oxygen:
- Not specifiedAir bubbled through the tanks for duration of exposure.
- Nominal and measured concentrations:
- Nominal:0, 100, 200, 400, 800 mg/l as Chromium III sulphate
Equivalent to 0, 31.5, 63, 126, 252 mg/l as Cr - Details on test conditions:
- TEST SYSTEM- Test vessel: Plastic containers measuring 20 x 40 x 60 cm holding 4 l of water- Aeration: Compressed air supplied to each tank throughout the test via submerged 1.5 cm3 diffusers- No. of organisms per vessel: 18 -20- No. of vessels per concentration (replicates): 2TEST MEDIUM / WATER PARAMETERS- Source/preparation of dilution water: tapwaterTEST CONCENTRATIONS- Test concentrations: 100, 200, 400 800 mg/l
- Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 97.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Cyprinus carpio
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 151.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Aristichthys nobilis
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 371.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Cyprinus carpio
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 363 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Aristichthys nobilis
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 30 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Cr 3+
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: C carpio
- Details on results:
- C. Carpio treated with 200 mg/l chromic sulphate had small particles in the gills of treated fish and a loss of epithelial cells. Lesions of the liver were observed with hypertrophy and congestion of the hepatic cells and small particles were noted in some cells. Imn the intestine, there was disintegration of epithelial cells and small particulates were observed in the microvilli region.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Considered scientifically valid although not meeting certain quality criteria. LC50 estimated in terms of Cr 3+ for C carpio is 30 mg/lLC50 estimated for Cr (OH)(NO3)2 for C carpio is111 mg/l
- Executive summary:
The effects of chromic sulphate on the common carp, Cyprinus carpio and the bighead, Aristichthys nobilis, were studied. C. carpio was found to be more susceptible than A. nobilis to chromic sulphate at the lowest concentration tested (100 mg/l) whereas results obtained at other concentration were similar for both species. Damage to the gills, liver and intestine was observed by histopathological examination
LC50 estimated in terms of Cr 3+ for C carpio is 30 mg/l
LC50 estimated for chromium hydroxychloride is ca 75 mg/l based on a nominal molecular weight of 130
Note that solublity in water under environmental conditions with a neutral pH is < 100 mg/l
Reference
Description of key information
LC50 estimated in terms of Cr 3+ for C carpio is 30 mg/l
LC50 estimated for chromium hydroxychloride is ca 75 mg/l based on a nominal molecular weight of 130
Note that solublity in water under environmental conditions with a neutral pH is < 100 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 75 mg/L
Additional information
Data on chloride suggests tolerance by freshwater species to be in excess of 100 mg/l Cl.
Many 'freshwater' sources have chloride > 100 mg/l.
Standard OECD hard test-water contains > 100 mg/l
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