Registration Dossier
Registration Dossier
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EC number: 217-682-2 | CAS number: 1929-82-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Authorative secondary source with limited data on methodology.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
- Principles of method if other than guideline:
- Secondary literature source no data about the method was available.
Test material
- Reference substance name:
- Nitrapyrin
- EC Number:
- 217-682-2
- EC Name:
- Nitrapyrin
- Cas Number:
- 1929-82-4
- Molecular formula:
- C6H3Cl4N
- IUPAC Name:
- 2-chloro-6-(trichloromethyl)pyridine
Constituent 1
Test animals
- Species:
- other: dog and rat
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- After oral administration of 14C-2-chloro-6-(trichloromethyl)pyridine to one female dog, at least 80% of the radioactivity was excreted via the urine as N-(6-chloropicolinoyl)glycine. No half-life time was given. After feeding 2-chloro-6-(trichloromethyl)pyridine spiked with 14C-2-chloro-6-(trichloromethyl)pyridine at 100 mg/kg diet for a number of days to rats, mainly 6-chloropicolinic acid and to a lesser extent N-(6-chloropicolinoyl)glycine were excreted.
Applicant's summary and conclusion
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