Propylamine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable study which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Method equivalent to Draize test.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propylamine

EC Number:

203-462-3

EC Name:

Propylamine

Cas Number:

107-10-8

Molecular formula:

C3H9N

IUPAC Name:

propan-1-amine

Details on test material:

Clear colorless liquid
No other data

Test animals / tissue source

Species:

rabbit

Strain:

other: albino

Details on test animals or tissues and environmental conditions:

No data

Test system

Vehicle:

not specified

Controls:

no

Amount / concentration applied:

0.1 ml

Duration of treatment / exposure:

-

Observation period (in vivo):

7 days

Number of animals or in vitro replicates:

6 (3: unwashed, and 3: washed)

Details on study design:

REMOVAL OF TEST SUBSTANCE
- Washing (if done): With three of the treated animals, the treated eye was washed with flowing water initiated 20 to 30 seconds after instillation and continued for 1 minute.
- Time after start of exposure: 20 to 30 seconds

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Results 2

Irritation parameter:

chemosis score

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

1

Max. score:

4

Reversibility:

not fully reversible within: 7 days

Results 3

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

>= 0

Reversibility:

not reversible

Remarks on result:

other: not scorable (black necrosis)

Results 4

Irritation parameter:

iris score

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

>= 0

Reversibility:

not reversible

Remarks on result:

other: not scorable (not visible)

Any other information on results incl. tables

Unwashed: the corneal opacified completely thus totally obscuring the iris. The conjunctivae became necrotic black with minimal chemosis. This ocular reaction occurred within seconds and showed no further change.

Scores at 1, 2 and 4 hours as well as daily for seven days remained persistently the same:

Cornea: 4

Iris: not scorable (not visible)

Conjunctival redness: not scorable (black necrosis)

Chemosis: 1

Washing did not alter the irritant reaction in any discernible manner. Scores were identical with those of unwashed eyes. Under these experimental conditions, mono-n-propylamine is considered corrosive to the eye.