Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information

According to the standard information requirements defined in Regulation 2006/1907, Annex VII, no data on reproductive toxicity are required. However, publically available information on reproductive toxicity of 2-chlorophenol is summarized below. As the available sources do not provide sufficient data for hazard evaluation, no key information is defined.

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

Limited data on reproductive toxicity of 2-chlorophenol is available (as cited in ATSDR, 2013).

2-chlorophenol was applied to female Sprague Dawley rats via drinking water beginning at weaning and extending through, rearing, mating and parturition (Exon and Koller, 1985, as cited in ATSRD, 2013). Concentrations ranging from 5 - 50 mg/kg bw/day were applied. The total exposure duration was approximately 13 weeks. A marginal decrease (p<0.10) in litter size at 30 mg/kg bw/day is reported. No significant reproductive effects were observed at 5 mg/kg bw/day.

 

References not included in IUCLID

Agency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences (ATSDR), 2013. Addendum to the toxicological profile for chlorophenols. Atlanta, GA 30333

Exon and Koller, 1985 (as cited in ATSDR, 2013). Toxicity of 2-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol, In: Jolley RL, ed. Water Chlorination: Chemistry, environmental impact and health effects. Volume 5. Fifth Conference on Water Chlorination: Environmental Impactand Health Effects, Williamsburg, VA, June 1984, 307-330.

Effects on developmental toxicity

Description of key information

According to the standard information requirements defined in Regulation 2006/1907, Annex VII, no data on (prenatal) developmental toxicity are required. However, publically available information on developmental toxicity of 2-chlorophenol is summarized below. As the available sources do not provide sufficient data for hazard evaluation, no key information is defined.

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

Limited data on developmental toxicity of 2-chlorophenol is available (as cited in ATSDR, 2013).

Pregnant rats were exposed to 2-chlorophenol at doses up to 50 mg/kg bw/day via the drinking water throughout gestation and up to 91 days post partum. No significant changes in offspring body or liver weights were observed in (Exon and Keller 1981, 1983, 1985, as cited in ATSDR, 2013). However, it has been shown that transplacental exposure to 2-chlorophenol can be feto- or embryotoxic at a high dose, resulting in a significant increase in the number of stillborn pups and decreased live litter size at 50 mg/kg bw/day (Exon and Koller 1982, 1985, as cited in ATSDR, 2013).

 

References not included in IUCLID

Agency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences (ATSDR), 2013. Addendum to the toxicological profile for chlorophenols. Atlanta, GA 30333

Exon and Koller, 1981 (as cited in ATSDR, 2013). Alteration of transplacental carcinogenesis by chlorinated phenols. In: Jolley RL, Brungs WA, Cotruvo WA, et al., eds. Water Chlorination: Environmental impact and health effects, Volume 4, Book 2. Ann Arbor, MI: Ann Arbor Science, 1177-1188.

Exon and Koller, 1982 (as cited in ATSDR, 2013). Effects of transplacental exposure to chlorinated phenols. Environ Health Perspect 46:137-140.

Exon and Koller, 1983 (as cited in ATSDR, 2013). Effects of chlorinated phenols on immunity in rats. Int J Immunopharmacol 5(2):131-136.

Exon and Koller, 1985 (as cited in ATSDR, 2013). Toxicity of 2-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol, In: Jolley RL, ed. Water Chlorination: Chemistry, environmental impact and health effects. Volume 5. Fifth Conference on Water Chlorination: Environmental Impact and Health Effects, Williamsburg, VA, June 1984, 307-330.

Justification for classification or non-classification

Based on the available data, no final decision on classification for reproductive or developmental toxicity can be made. However, taking into consideration the harmonized classification, 2-chlorophenol is not expected to exhibit hazardous properties in regard to fertility or embryonic/fetal development.