Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-433-2 | CAS number: 95-57-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
- Remarks:
- (no details on study design and results provided)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To evaluate the irritation potential towards the eyes, 0.1 mL test substance was instilled into the eyes of six rabbits for 1 min and 24 hrs. Irritation was determined at 1,24, 48, 72, 120 and 168 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chlorophenol
- EC Number:
- 202-433-2
- EC Name:
- 2-chlorophenol
- Cas Number:
- 95-57-8
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 2-chlorophenol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: KL1003
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- 1 min and 24 h
- Observation period (in vivo):
- 7 days
Reading time points: 1 min, 1, 24, 48, 72, 120 and 168 h - Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: cornea
- Basis:
- animal: 1-6
- Time point:
- other: 1 min and 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive within 1 min
- Irritation parameter:
- other: iris
- Basis:
- animal: 1-6
- Time point:
- other: 1 min and 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive within 1 min
- Irritation parameter:
- other: conjuncitvae
- Basis:
- animal: 1-6
- Time point:
- other: 1 min and 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive within 1 min
- Irritant / corrosive response data:
- The undiluted test substance was corrosive within 1 minute after instillation.
- Other effects:
- - Other observations: Severe discomfort was observed after test substance instillation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Category 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
