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Description of key information

Skin irritation (rabbit): corrosive

Eye irritation (rabbit): corrosive

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given
Remarks:
(no details on study design and results provided)
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate irritating properties towards the skin, the test substance was topically applied to the skin of six rabbits for 4 and 24 h. Local reactions were scored at 4, 24, 48, 72 und 168 h.
GLP compliance:
no
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Lot/batch No.of test material: KL 1003
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.5 mL

Duration of treatment / exposure:
4 and 24 h
Observation period:
21 days
Reading time points: 4, 24, 48, 72 and 168 h and daily afterwards until day 21
Number of animals:
6
Irritation parameter:
other: erythema
Basis:
animal: 1 - 6
Time point:
other: 4 h
Reversibility:
not reversible
Remarks on result:
other: severe erythema were observed (no scores given).
Irritation parameter:
other: edema
Basis:
animal: 1-6
Time point:
other: 4 h
Reversibility:
not reversible
Remarks on result:
other: severe edema were observed.
Irritant / corrosive response data:
Topical application for 4 h resulted in severe erythema and edema. When the test substance was applied for 24 h, eschar formation was observed. Loosening about edges of scab after 17 - 21 days showed injury in depth.
Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
CLP: Category 1
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given
Remarks:
(no details on study design and results provided)
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the irritation potential towards the eyes, 0.1 mL test substance was instilled into the eyes of six rabbits for 1 min and 24 hrs. Irritation was determined at 1,24, 48, 72, 120 and 168 hours.
GLP compliance:
no
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: KL1003
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.1 mL
Duration of treatment / exposure:
1 min and 24 h
Observation period (in vivo):
7 days
Reading time points: 1 min, 1, 24, 48, 72, 120 and 168 h
Number of animals or in vitro replicates:
6
Irritation parameter:
other: cornea
Basis:
animal: 1-6
Time point:
other: 1 min and 24 h
Reversibility:
not reversible
Remarks on result:
other: corrosive within 1 min
Irritation parameter:
other: iris
Basis:
animal: 1-6
Time point:
other: 1 min and 24 h
Reversibility:
not reversible
Remarks on result:
other: corrosive within 1 min
Irritation parameter:
other: conjuncitvae
Basis:
animal: 1-6
Time point:
other: 1 min and 24 h
Reversibility:
not reversible
Remarks on result:
other: corrosive within 1 min
Irritant / corrosive response data:
The undiluted test substance was corrosive within 1 minute after instillation.
Other effects:
- Other observations: Severe discomfort was observed after test substance instillation.
Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
CLP: Category 1
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation

The skin irritancy potential of 2-chorophenol was determined in a skin irritation study in white rabbits (NZW) (reference 7.3.1-1). The test substance was topically applied to the skin of six rabbits for 4 and 24 h. Local reactions were scored at 4, 24, 48, 72 und 168 h. All animals showed signs of corrosion at all observation time points after application. In detail, topical application for 4 h resulted in severe erythema and edema. When the test substance was applied for 24 h, eschar formation was observed. Loosening about edges of scab after 17 - 21 days revealed injury in depth. Based on the results of the conducted study, 2-chlorophenol is considered as corrosive to the skin.

Eye irritation

To evaluate the irritation potential towards the eyes, 0.1 mL undiluted test substance was instilled into the eyes of six white rabbits (NZW) for 1 min and 24 h (reference 7.3.2-1). The reactions were observed 1, 24, 48, 72, 120 and 168 h after treatment. All animals showed signs of corrosion at all observation time points after application. Based on the results of the conducted study, 2-chlorophenol is considered as corrosive to the eyes.

Justification for classification or non-classification

The available data on skin and eye irritation meet the criteria for classification as Skin Corr. Cat. 1 (H314) and Eye Dam. Cat. 1 (H318) according to Regulation (EC) 1272/2008.