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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
The toxicology of some glycols and derivatives.
Author:
Laug E, Calvery HO, Morris HJ, Woodward G
Year:
1939
Bibliographic source:
Journal of Industrial Hygiene and Toxicology 21: 173 - 201

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
11160, 12555, 13950, 16740, 19530, 20925, 22320 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
The animals were sacrificed after 5 days of observation.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
16 500 mg/kg bw
Mortality:
yes
Clinical signs:
Thirst, diuresis, ruffled coat and refusal of food were reported. After the first 2 to 3 days there was cessation of urine excretion with heavy proteinuria. Prostration, dyspnea, bloated appearance, coma, and pronounced lowering of body temperature were reported for about 24 hours before death.
Body weight:
no data
Gross pathology:
Histopathology:
- There was extensive degeneration of the renal cortex with vacuolar (hydropic) degeneration of the convoluted tubules.
- In the liver there was widespread diffuse hydropic degeneration of the central of lobules.
- The lung of some animals showed congestion, edema and focal interstitial pneumonia and hemorrhage in some cases.
- The spleen in many cases showed excessive phagocytosis of blood pigment.

Applicant's summary and conclusion