Registration Dossier

Administrative data

Description of key information

DEG is not considered to be sensitizing to the skin.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

BASF (1991) reported a guinea pig maximisation test conducted according to EU Method B.6. For intradermal induction a 5% diethylene glycol (DEG) formulation in NaCl and for epidermal induction a 75% DEG formulation in water were used. A 50% DEG formulation in water was applied for challenge. No skin reactions could be observed.

Monsanto (1967) reported a human repeated insult patch test. It was stated that diethylene glycol, in all cases, was capable of eliciting visible skin changes deemed characteristic of a primary skin irritant. It was not capable of eliciting visible skin changes deemed characteristic of a fatiguing agent or a skin sensitizer.

Thus, all data are indicative of DEG not to be a skin sensitizer.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available information classification for skin sensitisation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.