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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
hepatotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
No information
Author:
Siegers C.P. et al.
Year:
1974
Bibliographic source:
Pharmacology, 12, 296-302, (1974); cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxikologische Bewertung Nr.96, Ausgabe 01/97, BG Chemie,|Heidelberg, pp. 3-40, (1997)
Reference Type:
secondary source
Title:
No information
Author:
Siegers C.P. et al.
Year:
1974
Bibliographic source:
Pharmacology, 12, 296-302, (1974); cited in WHO: Environmental Health Criteria 65, WHO, Geneva,pp. 93 ff., (1987)

Materials and methods

Principles of method if other than guideline:
Hepatotoxicity and effects on liver enzymes were studied after single oral application in guinea pigs.
GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
single
Doses / concentrationsopen allclose all
Dose / conc.:
33.5 mg/kg bw (total dose)
Dose / conc.:
335 mg/kg bw (total dose)

Results and discussion

Details on results:
No hepatotoxic effects were found 16 hrs after single oral application of 33.5 or 335 mg/kg isobutanol to Pirbright-White guinea pigs. No difference in the enzyme activities of serum SGOT, SGPT, and GLDH and in the triglyceride concentration were detected compared to a olive oil control group.

Applicant's summary and conclusion