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Long-term toxicity to aquatic invertebrates

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To determine the long-term toxicity of iso-butanol to aquatic invertebrates, a non-GLP study on the reproduction of Daphnia magna was performed. The calculated NOEC (21d) in this study was 20 mg/L [Kuehn & al., 1989] and was used as the most sensitive value for the PNEC aqua. and the PNEC marine.