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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Dillingham E.O. et al.
Year:
1973
Bibliographic source:
J. Pharmaceut. Sci., 62, 22-30, (1973); cited in BG Chemie (ed.): 2-Methylpropanol-1, in:|Toxicological Evaluations 1 - Potential Health Hazards of Existing Chemicals, Springer Verlag, Berlin, pp. 43-57, (1990)

Materials and methods

Principles of method if other than guideline:
The test substance was applied i.p. to mice to determine the LC50.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Isobutanol

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Doses:
no data
No. of animals per sex per dose:
no data
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
312 mg/kg bw

Applicant's summary and conclusion