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EC number: 201-545-9
CAS number: 84-61-7
The absolute and relative liver weights
increased in the 100 and 500mg/kg dicyclohexyl phthalate groups. A
dam in the 500mg/kg dicyclohexyl phthalate group showed dystocia and
died on GD 23 before delivery was completed. No abnormal bodyweight
changes were detected in any group.
The viability index on PND 4 (%,
number of live pups on PND 4/number of live pups on PND 0×100) in the
500mg/kg dicyclohexyl phthalate group was lower than the control group,
and no abnormalities were detected in other reproductive parameters. The
body weights of male and female pups decreased signiﬁcantly in the
500mg/kg dicyclohexyl phthalate group at PND 14 and/or 21 (no data
shown). Hypospadia accompaniedwith small testes was detected in 2 male
rats in the 500mg/kg dicyclohexyl phthalate group and one of them was
sacriﬁced at 7 weeks of age for poor general condition. A prolonged
preputial separation, a reduced anogenital distance, and an increase in
areola/nipple retention were detected in the male rats in the 500mg/kg
dicyclohexyl phthalate group. No abnormalities in vaginal opening day or
estrous cycle were observed in any female group.
Group sacriﬁced at 10 weeks of age
The ventral prostate and levator
ani/bulbocavernosus muscle weights decreased in the 500mg/kg
dicyclohexyl phthalate group. Histologically, decreased testicular germ
cells and degenerated renal proximal tubules were detected in some male
rats in the 500mg/kg dicyclohexyl phthalate group.
No changes in the reproductive
parameters were detected in any dicyclohexyl phthalate-exposed group (no
Utero through lactational exposure assay
using dicyclohexyl phthalate to investigate the endocrine-mediated
effects of DCHP.Pregnant CD (SD) IGS rats were given dicyclohexyl
phthalate orally from gestational day (GD) 6 to postnatal day (PND) 20,
and the endocrine-mediated effects in dams and their offspring were
examined. The reproductive performance of offspring was also examined.
The doses of dicyclohexyl phthalate were 0, 20, 100, and 500mg/kg/day.
Using the dicyclohexyl phthalate, a dam in the 500mg/kg group showed
dystocia and died. The viability index of offspring on PND 4 decreased
in the 500mg/kg group. Prolonged preputial separation, reduced
anogenital distance, increased areolas/nipple retention, hypospadia,
decreased ventral prostate and levator ani/bulbocavernosus muscle
weights and decreased testicular germ cells were observed inmale
offspring in the 500mg/kg group The endocrine-mediated effects were
detected in offspring of dams given 100mg/kg dicyclohexyl phthalate.
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