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EC number: 201-545-9
CAS number: 84-61-7
The acute toxicity of
DICYCLOHEXYLPHTHALATE was investigated following a single oral
administration to the Sprague Dawley rat. The test item (batch 031-12)
was administered at 2000 mg/kg (dose volume of 10 mL/kg using corn oil
Animals were observed for a 14 day
period, then subjected to necropsy examination.
A first sub-group of 3 female
animals was initially dosed at 2000 mg/kg (Step 1). No mortality
occurred and no clinical signs were observed.
A second sub-group of 3 female
animals was then dosed at the same dose level (Step 2). No deaths
occurred and no clinical signs were noted.
Body weight changes recorded during
the study were within the expected range for this strain and age of
No abnormalities were observed in
any animal treated at necropsy examination performed at the end of the
These results indicate that the test
item DICYCLOHEXYLPHTHALATE did not induce effects in the rat following
oral administration of a single dose at a level of 2000 mg/kg. The lack
of mortality demonstrates the LD50 to be greater than 2000 mg/kg body
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