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EC number: 201-545-9
CAS number: 84-61-7
The potential of the test item,
DICYCLOHEXYLPHTHALATE, to cause corrosion/severe irritation by using the
Bovine Corneal Opacity and Permeability (BCOP) assay, was examined in
agreement with OECD Guideline no. 437 (adopted on) and OECD Supplement
to Test Guidelines nos. 437 and 438.
item was tested suspended at 20% (w/v) in physiological saline (being a
solid non surfactant) on the epithelial surface of three idoneous bovine
corneas, for an exposure period of 4 hours.
and negative controls [a 20% (w/v) Imidazole solution in physiological
saline and physiological saline alone, respectively] were concurrently
tested in similar condition.
opacity detected with an opacitometer at the end of the test item
exposure period was 0.1, comparable to the negative control.
determination of opacity, the epithelial surface was treated with a 0.5%
solution of sodium fluorescein in DPBS for 90 minutes, to investigate
alteration in cornea permeability.Mean
OD490value of the corneas treated with the test item was
unaffected by treatment, as well as the negative control.Negative
and positive controls gave the expected results.
The results obtained indicate that
the test item did not induce changes in both cornea opacity and
permeability under the reported experimental conditions. The calculated in
vitro irritancy score (IVIS) for the test item is 0.
According to the OECD Guideline no.
437, the test item is not to be classified as corrosive or severely
irritant to the eye.
Moreover, according to the criteria
stated in theOECD Supplement to Test Guidelines nos. 437 and 438, there
is no indication of irritant effect to the eye.
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