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EC number: 201-545-9
CAS number: 84-61-7
The objective of this study was to
evaluate the developmental toxic potential of dicyclohexyl phthalate
(DCHP) in rats. Pregnant Sprague–Dawley rats were exposed to DCHP at
doses of 0 (olive oil), 250, 500 and 750 mg kg-1 per day, by
gavage, on gestational days (GD) 6–20. Maternal food consumption and
body weight gain were significantly reduced at 500 and 750 mg kg-1 per
day of DCHP. Slight changes in liver weight associated with peroxisomal
enzyme induction were seen in dams treated with DCHP. DCHP produced
fetal growth retardation at 750 mg kg-1 per day, as evidenced
by significant reduction of fetal weight. DCHP induced a significant and
dose-related decrease in the anogenital distance of male fetuses at all
doses. In conclusion, DCHP showed no clear embryolethality and
teratogenicity. However, as Absolute
AGD was significantly reduced in male fetuses at all doses, the
lowest-observable-adverse-effect-level for developmental toxicity was
judged to be 250 mg kg-1 per day.
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