Registration Dossier
Registration Dossier
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EC number: 204-885-6 | CAS number: 128-42-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 128-42-7
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling Database
- Principles of method if other than guideline:
- Data is from DEPA
- GLP compliance:
- no
- Type of study:
- not specified
Test material
- Reference substance name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- EC Number:
- 204-885-6
- EC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Cas Number:
- 128-42-7
- Molecular formula:
- C14H10N2O10S2
- IUPAC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: no data
- Vehicle:
- no data
Challenge
- Route:
- other: no data
- Vehicle:
- no data
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- other: no data
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- Details not available
- No. with + reactions:
- 0
- Clinical observations:
- Skin sensitization : Negative i.e not sensitising
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: Details not available. No with. + reactions: 0.0. Clinical observations: Skin sensitization : Negative i.e not sensitising.
Any other information on results incl. tables
Skin sensitization : Negative i.e not sensitising
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In vivo studies on humans for skin sensitisation with 4,4'-dinitrostilbene-2,2'-disulphonic acid exhibits negative skin sensitisation results.
- Executive summary:
In vivo studies on humans for skin sensitisation with 4,4'-dinitrostilbene-2,2'-disulphonic acid exhibits negative skin sensitisation results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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