Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-885-6 | CAS number: 128-42-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- DPIM : DVF600
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials) : Gigiena i Sanitariya. 45(3) (1980), 73.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : WJ6625000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances): Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),73,1980
- Reference Type:
- other: Authoritative data base
- Title:
- GCID : 56738
- Author:
- ACTOR Database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource) : Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 73, 1980.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX, RTECS and ACTOR
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- EC Number:
- 204-885-6
- EC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Cas Number:
- 128-42-7
- Molecular formula:
- C14H10N2O10S2
- IUPAC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 71 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Lethal dose, 50 percent kill
- Other findings:
- Toxic Effects : Liver - liver function tests impaired Kidney/Ureter/Bladder - renal function tests depressed
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 4,4'-dinitrostilbene-2,2'-disulphonic acid in Rodent guinea pig on the basis of mortality effect was found to be 71000 mg/kg of body weight. This value indicates that 4,4'-dinitrostilbene-2,2'-disulphonic acid does not exhibits acute toxicity by the oral route.
- Executive summary:
The acute oral median lethal dose (LD50) of 4,4'-dinitrostilbene-2,2'-disulphonic acid in Rodent guinea pig on the basis of mortality effect was found to be 71000 mg/kg of body weight. This value indicates that 4,4'-dinitrostilbene-2,2'-disulphonic acid does not exhibits acute toxicity by the oral route.
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