Registration Dossier
Registration Dossier
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EC number: 249-044-4 | CAS number: 28472-97-1
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
Toxicity to sediment organisms is unlikely.
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity to sediment organisms is available for Diisodecyl azelate (CAS 28472-97-1). Since the substance is readily biodegradable, chronic exposure of sediment organisms is unlikely. In addition, available data indicate, that the substance is not bioaccumulative. Based on the available information, toxicity to sediment organisms is not expected to be of concern. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2012b). Therefore, after passing through conventional STPs, only low concentrations of this substance are likely to be (if at all) released into the environment.
Aquatic ecotoxicity data
Based on experimental data, Diisodecyl azelate exhibits no acute up to the limit of water solubility and low chronic toxicity to aquatic organisms (nominal loading rate above water solublity).
Metabolisms/Bioaccumulation
After absorption, Diisodecyl azelate is expected to be enzymatically hydrolysed in vivo by the ubiquitary enzyme carboxylesterase, yielding the corresponding alcohol and dicarboxylic acid. QSAR estimations using BCFBAF v3.0 support the expected rapid biotransformation of this substance with BCF/BAF values of 0.9 and 1.1 L/kg, respectively (Arnot-Gobas estimation including biotransformation, upper trophic level). The metabolism of the hydrolysis products alcohol (e.g. Isodecanol) and dicarboxylic acid (e.g. Azelaic acid) is well established and not of concern in terms of bioaccumulation (for further information see chapter 5.3 of the technical dossier).
Conclusion
Due to its readily biodegradable nature, extensive degradation of Diisodecyl azelate in conventional STPs will take place and only low concentrations are expected to be released (if at all) into the environment. After uptake by sediment species, extensive and fast biotransformation of this substance by carboxylesterases into Azelaic acid and the corresponding alcohol is expected. The supporting BCF/BAF values estimated with the BCFBAF v3.01 program, Arnot-Gobas model including biotransformation, also indicate that this substance will not be bioaccumulative. Therefore, Diisodecyl azelate is unlikely to pose a risk for sediment organisms in general and testing is thus omitted. A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within CSR.
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