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EC number: 249-044-4
CAS number: 28472-97-1
Toxicity to sediment organisms is unlikely.
No experimental data evaluating the toxicity to sediment organisms
is available for Diisodecyl azelate (CAS 28472-97-1). Since the
substance is readily biodegradable, chronic exposure of sediment
organisms is unlikely. In addition, available data indicate, that the
substance is not bioaccumulative. Based on the available information,
toxicity to sediment organisms is not expected to be of concern.
According to the Guidance on information requirements and chemical
safety assessment, Chapter R.7b, readily biodegradable substances can be
expected to undergo rapid and ultimate degradation in most environments,
including biological Sewage Treatment Plants (STPs) (ECHA, 2012b).
Therefore, after passing through conventional STPs, only low
concentrations of this substance are likely to be (if at all) released
into the environment.
Aquatic ecotoxicity data
Based on experimental data, Diisodecyl azelate exhibits no acute
up to the limit of water solubility and low chronic toxicity to aquatic
organisms (nominal loading rate above water solublity).
After absorption, Diisodecyl azelate is expected to be
enzymatically hydrolysed in vivo by the ubiquitary enzyme
carboxylesterase, yielding the corresponding alcohol and dicarboxylic
acid. QSAR estimations using BCFBAF v3.0 support the expected rapid
biotransformation of this substance with BCF/BAF values of 0.9 and 1.1
L/kg, respectively (Arnot-Gobas estimation including biotransformation,
upper trophic level). The metabolism of the hydrolysis products alcohol
(e.g. Isodecanol) and dicarboxylic acid (e.g. Azelaic acid) is well
established and not of concern in terms of bioaccumulation (for further
information see chapter 5.3 of the technical dossier).
Due to its readily biodegradable nature, extensive degradation of
Diisodecyl azelate in conventional STPs will take place and only low
concentrations are expected to be released (if at all) into the
environment. After uptake by sediment species, extensive and fast
biotransformation of this substance by carboxylesterases into Azelaic
acid and the corresponding alcohol is expected. The supporting BCF/BAF
values estimated with the BCFBAF v3.01 program, Arnot-Gobas model
including biotransformation, also indicate that this substance will not
be bioaccumulative. Therefore, Diisodecyl azelate is unlikely to pose a
risk for sediment organisms in general and testing is thus omitted. A
detailed reference list is provided in the technical dossier (see
IUCLID, section 13) and within CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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