Registration Dossier
Registration Dossier
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EC number: 204-171-4 | CAS number: 117-08-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, acceptable with restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Reference Type:
- publication
- Title:
- HPV Chemicals Challenge Program. Revised test plan for 4,5,6,7-tetrachloro-1,3-isobenzofurandione CAS no. 117-08-8
- Author:
- Solutia Inc.
- Year:
- 2 003
- Bibliographic source:
- Received OPPT CBIC 2003 May 22 (201-14481A, IUCLID Data set received OPPT CBIC 2003 May 22 (201-14481B)
- Reference Type:
- publication
- Title:
- Effect of tetrachlorophthalic anhydride on hepatic microsomal metabolism in rats and mice.
- Author:
- Ridley WP, Warren J, Nair RS
- Year:
- 1 988
- Bibliographic source:
- J Toxicol Environ Health 24: 217-227
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Groups of single rabbits were treated dermally with either 501 (1F), 794 (1M), 1260 (1F), 2000 (1M), 3160 (1F) or 5010 (1M) mg/kg bw test article (ground powder in a 10% corn oil suspension) to define a Minimum Lethal Dose. All animals had their dorsal region closely shaved and test material applied to intact skin under an occlusive patch and held in place for 24 hours. Thereafter, the test article was wiped off. All animals were observed daily for signs of toxicity and weighed prior to and at study term (5 days).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- Molecular formula:
- C8Cl4O3
- IUPAC Name:
- tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report): Tetrachlorophthalic anhydride
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- the test article was wiped off
- Time after start of exposure: 24 h
VEHICLE
- Amount(s) applied (volume or weight with unit): ground powder in a 10% corn oil suspension - Duration of exposure:
- 24 h
- Doses:
- 501, 794, 1260, 2000, 3160 and 5010 mg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 days
- Frequency of observations and weighing: all animals were observed daily for signs of toxicity and weighed prior to and at study term
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Mortality:
- no mortalities were observed
Any other information on results incl. tables
No further details are reported.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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