Registration Dossier
Registration Dossier
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EC number: 204-171-4 | CAS number: 117-08-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
Several groups of 1 to 3 female rats were treated by gavage with preparations of the test substance in 1, 10 and 20% tragacanth solutions, respectively. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
3 animals of the high dose group were sacrificed 31 days after gavage and subjected to gross pathological examinations. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- Molecular formula:
- C8Cl4O3
- IUPAC Name:
- tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report): Tetrachlorophthalic anhydride
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 140-206 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tragacanth
- Doses:
- 20, 79, 316, 1260, 5010, 7940 and 10000 mg/kg bw
- No. of animals per sex per dose:
- 1-5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- No death occurred during observation period.
- Clinical signs:
- other: No clinical symptoms.
- Gross pathology:
- At necropsy no gross pathological changes were observed.
Any other information on results incl. tables
Dose (mg/kg bw) |
Mortality (Dead/Treated) |
||
24 h |
48 h |
7 d |
|
20 |
0/1 |
0/1 |
0/1 |
79 |
0/1 |
0/1 |
0/1 |
316 |
0/1 |
0/1 |
0/1 |
1260 |
0/1 |
0/1 |
0/1 |
5010 |
0/1 |
0/1 |
0/1 |
7940 |
0/2 |
0/2 |
0/2 |
10000 |
0/5 |
0/5 |
0/5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
