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EC number: 221-264-5
CAS number: 3049-71-6
Particle Size Analysis:
For determination of the acute inhalation toxicity (single
4-hour-exposure) of the test substance as dust, a GLP compliant study in
male and female Wistar rats was performed according to OECD-Guideline
method 403, as well as EEC and EPA guidelines. A measured concentration
of 5 .2 mg/I was tested (Limit test). Cascade impactor measurements
resulted in particle size distributions with mass median aerodynamic
diameters (MMADs) of 3.0 and 3.1 µm, which are well within the
respirable range. No mortality occurred at the tested concentration.
Clinical signs of toxicity comprised visually accelerated respiration,
pulmonary respiration sounds, squatting posture, piloerection and
smeared fur. Findings were observed from hour 0 of exposure until
including study day 3. Moreover, contaminated fur was observed in all
animals from day 0 onward until termination of the study. The mean body
weights of the animals increased throughout the study period. No
pathological abnormalities of the organs were observed in all animals at
termination of the study. Contaminated fur was noted during necropsy in
all animals. Under the conditions of this study the LC50 for male and
female rats after dust inhalation was > 5 .2 mg/l.
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