Registration Dossier
Registration Dossier
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EC number: 203-851-8 | CAS number: 111-26-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable Guideline and GLP study
Data source
Reference
- Reference Type:
- publication
- Title:
- FOA rapport E 40026
- Author:
- Koch B. et al.,
- Year:
- 1 985
- Bibliographic source:
- FOA rapport E 40026, Försvarets Forskningsanstalt
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexylamine
- EC Number:
- 203-851-8
- EC Name:
- Hexylamine
- Cas Number:
- 111-26-2
- Molecular formula:
- C6H15N
- IUPAC Name:
- hexan-1-amine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: 0.1 mL
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 9
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: a severe necrotic effect was observed
- Irritant / corrosive response data:
- After an exposition time of respectively 4 and 30 seconds: only one animal showed irritation of the cornea, conjunctivae redness and conjunctivae swelling. After an exposition time of 24 hrs: all tested animals showed irritation of the cornea and of the iris, conjunctivae redness and conjunctivae swelling and a severe necrotic effect was observed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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