Registration Dossier
Registration Dossier
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EC number: 203-851-8 | CAS number: 111-26-2
Endpoint summary
Administrative data
Description of key information
Additional information
Phototransformation in air
After evaporation or exposure to the air, the product will be rapidly degraded by photochemical processes.
Hydrolysis
As the substance is ready biodegradability an experimental investigation of its hydrolytic properties was not considered necessary. Further, according to Kollig et al. (1993) and Boethling & Mackay (2000) amines and alcohols are generally resistant to hydrolysis because they do not contain labile functional groups.
Biodegradation
Based on a weight-of-evidence-approach using QSAR-data as well as experimentally derived data from two analogous compounds hexylamine is considered to be readily biodegradable.
Bioaccumulation
Based on a low measured log Kow-value of 2.06 and predicted BCF-values below 100 the bioaccumulation potential of the substance is considered to be low.
Adsorption / desorption
In accordance with column 2 of REACH Annexes VIII and IX, the study does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient), or the substance and its relevant degradation products decompose rapidly. The substance has a log Kow of 2.06 (@ 25 °C) and is readily biodegradable.
In addition the Koc value was estimated using QSAR models. According to the MCI method of the KOCWIN v2.00 module of EPI Suite v4.11, the substance has a log Koc of 2.17 (Koc 146.9). The MCI module is more reliable than the second method of KOCWIN v2.00, which estimates the KOC based on the log Kow. The latter method resulted in a log Koc of 2.043 (Koc of 110).These estimates are representative for uncharged molecules.
At environmentally relevant conditions, the substance will be present in ionised form (pKa = 10.7 (@ 25 °C)). Therefore the adsorption coefficient was calculated according to Franco & Trapp (2008, 2009, 2010) to correct for the charged molecule at pH 5, 7, and 8. The resulting Koc at pH 7 is ca. 1309 (range pH 5 to 8: 1307-1309). It can be concluded that significant adsorption to the solid soil phase is not to be expected.
Distribution
The test substance does not significantly vaporize from the water surface into the atmosphere. The volatility of 2.73 Pa*m3/mol was reported by Christie and Crisp,1967.
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