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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation (based on immediate and violent reactivity of PTSI with water): irritating to skin
Eye irritation (based on immediate and violent reactivity of PTSI with water): irritating to eyes
Respiratory irritation (based on immediate and violent reactivity of PTSI with water): irritating to respiratory tract

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation / corrosion
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The results of PTSA are not read across to PTSI. PTSI is extremely reactive with water and reacts instantaneously into the source substance PTSA. This will readily occur on the skin and also in the eye upon exposure to PTSI. Thus, although final exposure will be to PTSA and not PTSI, the initial violent reaction of PTSI with water justifies its classification for skin and eye irritation. Moreover, due to its extreme reactivity it is considered unethical to perform the skin and eye irritation/corrosion studies on animals with PTSI as such.

According to Annex VI of CLP, PTSI is also classified as irritating to the respiratory tract.


Justification for selection of skin irritation / corrosion endpoint:
A pre-GLP study similar to the OECD Guideline 404, but with some deviations, with PTSA, the direct reaction product of PTSI, showed that PTSA is not irritating to skin. However, because of the immediate violent exothermic reactivity of PTSI with water/moisture, it is considered appropriate to classify PTSI for skin irritation.

Justification for selection of eye irritation endpoint:
A pre-GLP study similar to the OECD Guideline 405, but with some deviations, with PTSA, the direct reaction product of PTSI, showed that PTSA is not irritating to eyes. However, because of the immediate violent exothermic reactivity of PTSI with water/moisture, it is considered appropriate to classify PTSI for eye irritation.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Based on its extreme reactivity with water, PTSI is considered to meet the criteria for classification and will require labelling for skin and eye irritation in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP) and Annex VI of 67/548/EEC (DSD).

Based on Annex VI of 1272/2008/EC (CLP), PTSI is also considered to meet the criteria for classification and will require labelling for respiratory irritation.