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EC number: 204-706-1 | CAS number: 124-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2007-06-07 to 2009-06-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- methanesulfonyl chloride
- Details on test material:
- - Name of test material: Methanesulfonyl chloride
- Lot/batch No.: MSC B14GPD/Arkema
- Purity: > 99.9%
- Date of receipt: 2007-03-15
- Appearance: colourless or yellow liquid
- Water solubility: 1100 mg/L at 20 °C
- Density at 20°C: 1478 kg/m3
- Dissolved in water
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not relevant
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sample storage before analysis: no storage
- Samples treatment: direct analysis
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION
A stock solution of the test item diluted in water was prepared one day (22 hours) before the beginning of the test (time 0) by mixing 100 mg (67.7µL) of MSC in 1 L of dilution water for preliminary and definitive test.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus (Cladocera, Crustacea)
- Strain: clone 5 or clone A
- Source: come from a stock breading in the laboratory reared in VOLVIC® water added with vitamin B12, Na2SeO3, 5H2O, spiruline, Calcium, Magnesium unicellular green fresh-water algae Pseudokirchneriella subcapitata and Chlorella Vulgaris.
- Age at study initiation: less than 24 hours
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- no data
- Test temperature:
- remained between 18 and 22 °C
- pH:
- At the beginning of the test, from 7.24 to 4.68 (concentration 50 mg/L).
At the end of the test, from 7.20 to 5.05 (concentration 50 mg/L).
pH is considerably lowered for the higher nominal concentrations of the test item due to the hydrolysis of the substance into MSA. - Dissolved oxygen:
- from 8.2 to 9.1 mg/L O2
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentrations: 10 - 13.8 - 19 - 26.3 - 36.2 and 50 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 30 mL glass bottles stoppered with PTFE bungs and sealed with aluminium caps
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Renewal: no
TEST MEDIUM / WATER PARAMETERS
- Ultrapure water used for the preparation of dilution water (resistivity > 18MΩ).
OTHER TEST CONDITIONS
- test flasks incubated in darkness
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.38 - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 34 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 45 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- EC50 values determined at 24 and 48h post exposure based on nominal concentrations for Methanesulfonic Acid (MSA):
- EC50-24h = 38 mg/L
- EC50-48h = 29 mg/L - Results with reference substance (positive control):
- EC50 obtained on 31/05/2007 was 0.95 mg/L.
- Reported statistics and error estimates:
- The inhibition of mobility data are analyzed using an Excel program. It was designed to calculate the EC50 value and the 95% confidence interval. Probit analysis is generally used to calculate the 24 and 48-hour EC50 values.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- See conclusions
- Conclusions:
- Quality criteria:
- The immobilisation in the control should not exceed 10 per cent at the end of the test;
- Daphnids in the control have not be trapped at the surface of the water;
- The dissolved oxygen concentration remained above 3 mg/L over the test period. - Executive summary:
Acute toxicity of Methanesulfonyl chloride to Daphnia magna has been investigated through OECD Guideline 202.
Daphnia magna were exposed for 48 hours to an aqueous solution of Methanesulfonyl chloride at different nominal concentrations of 10 - 13.8 - 19 - 26.3 - 36.2 and 50 mg/L.
EC 50 - 48h determined is of 34 mg/L and EC50 - 24h is of 45 mg/L. As the substance is known to hydrolyze quite easily into methanesulfonic acid (MSA), EC50 -48h and EC50 -24h were calculated for MSA, and were respectively of 29 mg/L and 38 mg/L.
The quality criteria were fulfilled.
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