Methanesulphonyl chloride

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Draize Test (eyes not rinsed)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methanesulphonyl chloride

EC Number:

204-706-1

EC Name:

Methanesulphonyl chloride

Cas Number:

124-63-0

Molecular formula:

CH3ClO2S

IUPAC Name:

methanesulfonyl chloride

Details on test material:

Test article name : Methane sulfonyl chloride
Cas n°: 124-63-0
Origin: Pennwalt Corporation
Batch no. : no data
Purity: no data

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Species: Rabbit
- Strain: albino
- Source: no data
- Age: no data
- Weight at dosing: no data
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Housing: no data
- Diet: no data
- Water: no data
- Temperature: no data
-Humidity: no data
-Air changes: no data
- Photoperiod: no data

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

Amount applied: 0.1 ml

Duration of treatment / exposure:

not rinced

Observation period (in vivo):

The resulting reactions were scored for 7 days.

Number of animals or in vitro replicates:

3

Results and discussion

In vivo

Results

Irritation parameter:

other: Corrosivity

Time point:

other: 1 hour to 7 days

Reversibility:

not reversible

Remarks on result:

other: Opacification of the cornea completely obscured the iris and the  conjunctivae became necrotic white (dead) without chemosis

Irritant / corrosive response data:

All animals screamed in pain following instillation. Opacification of the cornea completely obscured the iris and the  conjunctivae became necrotic white (dead) without chemosis. These effects appeared promptly and remained unaltered thereafter.

Any other information on results incl. tables

Average scores:

Time    Cornea   Iris    enanthema    edema
------------------------------------------------
1 h        4        ?        W         0
2 h        4        ?        W         0        
3 h        4        ?        W         0
4 h        4        ?        W         0

24 h       4        ?        W         0
48 h       4        ?        W         0
72 h       4        ?        W         0

4 d        4        ?        W         0
5 d        4        ?        W         0
6 d        4        ?        W         0
7 d        4        ?        W         0
-------------------------------------------------
W: white necrosis

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye)

Remarks:

Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008

Executive summary:

0.1 ml of methanesulfonyl chloride (purity unknown) was placed in the conjunctival sac of one of each of 3 rabbits. The resulting reactions were scored for 7 days.All animals screamed in pain following instillation. Opacification of the cornea completely obscured the iris and the conjunctivae became necrotic white (dead) without chemosis. These effects appeared promptly and remained unaltered thereafter.