Registration Dossier
Registration Dossier
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EC number: 437-930-5 | CAS number: 51553-03-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 437-930-5
- EC Name:
- -
- Cas Number:
- 51553-03-8
- Molecular formula:
- Hill formula: C22H23N7O5 CAS formula: C22H23N7O5
- IUPAC Name:
- N-{5-[bis(2-methoxyethyl)amino]-2-[2-(2,6-dicyano-4-nitrophenyl)diazen-1-yl]phenyl}acetamide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- other: Ratte rat (Wistar)
Administration / exposure
- Vehicle:
- other: Propylenglykol Das Vehikel wurde aufgrund eines Vorversuchs ausgewählt. Propylene glycol The vehicle was selected based on a pretest.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Zwischen Tag 1 und Tag 3 wurde Lethargie und/oder zusammengekauerte Haltung bei den Versuchtieren beobachtet. Die durchschnittliche Zunahme des Körpergewichts der Ratten während der Studie entspricht der zu er
- Gross pathology:
- Effects on organs:
Bei der Nekropsie sind keine makroskopischen Abnormalitäten
festgestellt worden.
No abnormalities were found at macroscopic post mortem
examination of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value of BDF 054-1 in Wistar rats was established to exceed 2000 mg/kg body weight.
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