Registration Dossier
Registration Dossier
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EC number: 213-485-0 | CAS number: 957-68-6
Stability: thermal, sunlight, metals
Administrative data
- Endpoint:
- stability: thermal, sunlight, metals, other
- Remarks:
- Migrated from section 'Stability: thermal, sunlight, metals'
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD113) with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 213-485-0
- EC Name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 957-68-6
- Molecular formula:
- C10H12N2O5S
- IUPAC Name:
- (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: 7-Aminocefalosporansäure (7-ACA)
Lot no.: 34212818
Constituent 1
Results and discussion
For thermal stability study
- Test substance thermally stable:
- no
Operating temperature
- Operating temp.:
- > 25 - < 270 °C
- Sublimation:
- not determined
- Transformation products:
- not measured
Applicant's summary and conclusion
- Conclusions:
- The differential scanning calorimetry in a closed glass crucible showed a sharp decomposition signal in the temperature range of 160 - 230 °C with a decomposition energy of -400 J/g.
- Executive summary:
The thermal stability of a substance was determined using Difference Scanning Calorimetry (DSC). Therefore, some milligrams of the substance were weighed into a glass crucible which was fused by an oxyhydrogen flame. So the crucible was prepared to be placed into the DSC-apparatus in order to determine the thermogram of the sample. The sample is measured in comparison to a glass crucible filled with aluminiumoxide. Both crucibles are heated with a heating rate of 3 K/min.
The preparation of the substances is carried out under ambient atmosphere. Hence there is residual oxygen locked within the crucible after the fusing. During the test, this residual Oxygen can react with the substance and thus cause heat generation of approxymately ‑20 J/g. Because of the low heat generation and the minor amount of oxygen, this effect can be neglected.
The DSC-equipment is regularly calibrated according to established standards. Subsequent to that the heat generation of a chemical reaction can be reliably determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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