3-(chloromethyl)heptane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test was performed in principle as described in OECD test guideline 403 - Annex (1981). It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20°C. Young adult laboratory rats, 6 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. The exposure was subsequently repeated in the same manner. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.

GLP compliance:

no

Remarks:

GLP was not compulsory at the time the study was conducted

Test type:

other: Inhalation Hazard Test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethylhexylchloride

IUPAC Name:

Ethylhexylchloride

Details on test material:

- Name of test material (as cited in study report): Ethylhexylchloride
- Physical state: liquid
- Purity: ca. 98%

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: young adult
- Body weight at study initiation:
IHT 20°C experiment 1: group weight females 620 g (3 animals), group weight males 755 g (3 animals)
IHT 20°C experiment 2: group weight females 588 g (3 animals), group weight males 680 g (3 animals)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Remarks on duration:

at 20°C

Concentrations:

No verification of the concentration was performed. Nominal concentration: 11.1 mg/l (= 1820 ppm)

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- The animals were examined for mortality and clinical signs of toxicity
- Frequency of observations: several times at the application day and thereafter once each working day
- Body weights were recorded group-wise at the beginning and the end of the study
- Necropsy of survivors and animals which died performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 11.1 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: IHT; 20°C; No mortalities observed

Mortality:

No mortalities observed.

Clinical signs:

other: Strong irritation of mucous membranes.

Body weight:

- Body weight at the end of the study:
IHT 20°C experiment 1: group weight females 715 g (3 animals), group weight males 843 g (3 animals)
IHT 20°C experiment 2: group weight females 671 g (3 animals), group weight males 769 g (3 animals)

Gross pathology:

Nothing abnormal detected.