Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 406-420-4 | CAS number: 69430-40-6 DC 5067
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 April - 04 June, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to GLP.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))
- EC Number:
- 406-420-4
- EC Name:
- α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))
- Cas Number:
- 69430-40-6
- Molecular formula:
- Unspecified example: C18.3H46.8O5.8Si4.1
- IUPAC Name:
- 2,2,4,4,6,12,15-heptamethyl-6-[(trimethylsilyl)oxy]-3,5,10,13,16-pentaoxa-2,4,6-trisilaheptadecane
- Details on test material:
- - Name of test material (as cited in study report): DOW CORNING 2-5067 Surfactant
- Substance type: Reaction mass (mixture)
- Physical state: Liquid
- Analytical purity: > 99%
- Lot/batch No.: 0000771635
- Expiration date of the lot/batch: December 13, 2003
- Stability under test conditions: Stable
- Storage condition of test material: In the original container at room temperature in the dark
- Other:
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Water accomodated fractions used due to poor water solubility of the test substance..
- Basis for effect:
- growth rate
- Remarks on result:
- other: n/a
Any other information on results incl. tables
Combined Limit/range-finding test:
The mean cell densities measured during the combined limit/range-finding test are presented in Table 1. Table 2 presents the percentages growth inhibition and growth rate reduction per concentration. No significant treatment related effects on algal growth rate were observed during the test period.
Table 1: Mean cell densities (x 104 cells/ml) during the combined limit/range finding test.
DOW CORNING® 2-5067 SURFACTANT WAF at x mg/l | Exposure Time (hours) | ||||
0 | 24 | 48 | 72 | ||
Blank-control | 1.0 | 2.2 | 24.5 | 105.2 | |
0.1* | 1.0 | 2.6 | 26.0 | 106.9 | |
1 | 1.0 | 3.0 | 22.2 | 90.2 | |
10 | 1.0 | 2.3 | 21.8 | 93.7 | |
100 | 1.0 | 2.8 | 20.8 | 82.8 |
* Ten-fold dilution from the WAF prepared at 1 mg/l
Table 2: Percentage reduction of growth rate and inhibition of total growth during
the combined limit/range finding test
DOW CORNING® 2-5067 SURFACTANT WAF at x mg/l | Cell growth (0 - 72 hrs) | Mean growth rate | |||
Mean area (A) | Inhibition (%) | µ (0 - 72 hours) | Reduction (%) | ||
Blank-control | 1843.54 | 0.06444 | |||
0.1* | 1909.57 | -3.6 | 0.06486 | -0.7 | |
1 | 1626.44 | 11.8 | 0.06234 | 3.3 | |
10 | 1644.35 | 10.8 | 0.06306 | 2.2 | |
100 | 1493.97 | 19.0 | 0.06101 | 5.3 |
* Ten-fold dilution from the WAF prepared at 1 mg/l
Analyses of samples taken at the highest tested concentration, being a Water Accomodated Fraction (WAF) prepared at 100 mg/l, did not result in reliable resuIts. As a cansequence, the Analytical (extraction) method was improved. After the extraction procedure was improved, the project was continued with a limit test as no significant effects were expected.
Hence, both the EL50, for cell growth lnhibition and growth rate reduction were expected to be above the concentration reached after preparation of a WAF at a nominal loading of 100 mg/l.
Limit test:
The mean cell densities measured during the limit test are presented in Table 3. Table 4 presents the percentages growth inhibition and growth rate reduction per concentration. Unexpectedly, algal cell growth was more inhibited (46%) than observed during the combined limit/range-finding test (19%). Simultaneously, growth rate was biologically significantly reduced (14%). No clear founded reason for this inconsistency could be given. It was thought that the differences in effects were related to the nature of the test substance, i.e. a mixture with various components with various solublllty limits. Hence, one or more components could have been present in different concentrations when comparing the test solutions in the limit test with those prepared in the combined limit/range-finding test. This problem often rises when testing WAFs. It was decided to continue testing with a range of WAFs prepared at loadings between 5.6 and 56 mg/l in order to be able to define a NOELR.
Analyses of the samples was based on the two major peaks that were observed in the chromatograms. No correlation could be given between the observed peaks and the various test substance components. The measured concentration in the WAF prepared at 100 rng/l corresponded with approximately 20 mg/l at the start and decreased to ca. 10 m/l at the end of the test period (results were comparable for both peaks; see Tables 4 and 5 of the appended Analytical report). Temperalure and pH were maintained within the optimum limits for testing with algae.
Table 3: Mean cell densities (x 104 cells/ml) during the limit test.
DOW CORNING® 2-5067 SURFACTANT WAF at x mg/l | Exposure Time (hours) | ||||
WAF at mg/l | Actual (mg/l) | 0 | 24 | 48 | 72 |
Blank-control | 1.0 | 5.0 | 37.6 | 150.2 | |
100 | 20 - 10 | 1.0 | 5.8 | 22.0 | 73.7 |
Actual (mg/l) based on analyses of the two major peaks at t=0 and t= 72 hours
Table 4: Percentage reduction of growth rate and inhibition of total growth during the limit/range test
DOW CORNING® 2-5067 SURFACTANT WAF at x mg/l | Cell growth (0 - 72 hrs) | Mean growth rate | |||
WAF at mg/l | Actual (mg/l) | Mean area (A) | Inhibition (%) | µ (0 - 72 hours) | Reduction (%) |
Blank-control | 2763.50 | 0.06959 | |||
100 | 20 - 10 | 1493.27 | 46.0 | 0.05969 | 14.2 |
Actual (mg/l) based on analyses of the two major peaks at t=0 and t= 72 hours
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- details see attached study report, p.6
- Conclusions:
- Under the conditions of the present study wiih Selenastrum capricornutum, no significant reduction of growth rate was recorded at any of the loadings of DOW CORNING(R) 2-5067 SURFACTANT tested. The NOELR equalled a WAF loaded at 100 mg/l.
- Executive summary:
Selenastrum capricornutum, Fresh Water Algal Growth Inhibition Test with DOW CORNING(R) 2-5067 SURFACTANT.
The batch of DOW CORN ING(R) 2-5067 SURFACTANT tested was a slightly yellowish coloured liquid. DOW CORNING(R) 2-5067 SURFACTANT is a mixture consisting of at last 9 different components. The test substance was not completely soluble in test medium at the concentrations tested. Owing to the poor solubifity of the test substance and the fact that the test substance was a mixture, it was decided to separately prepare Water Accomodated Fractions (WAFs) at various nominal loadings. A 24-hour magnetic stirring period was followed by phase separation for either 4 or 24 hours. The water fractions were then tested.
A limit test and a range-finding test combined with a limit test were conducted. The initial cell density was 104 cells/ml. The total test period was 72 hours. Samples for determination of actual exposure concentrations were in general taken at the start, after 24 hours and at the end of the test period. Analyses were based on the two major peaks observed in the chromatograms of the DOW CORNING(R) 2 -5067 SURFACTANT mixture. Results are presented in tables 1 - 4 under Results and Discussions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.