α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

6 - 30 May, 1991

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1992

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))

EC Number:

406-420-4

EC Name:

α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))

Cas Number:

69430-40-6

Molecular formula:

Unspecified example: C18.3H46.8O5.8Si4.1

IUPAC Name:

2,2,4,4,6,12,15-heptamethyl-6-[(trimethylsilyl)oxy]-3,5,10,13,16-pentaoxa-2,4,6-trisilaheptadecane

Details on test material:

- Name of test material (as cited in study report): DC 5067
- Substance type: Reaction mass (mixture)
- Physical state: Liquid
- Analytical purity: > 99%
- Lot/batch No.: AB 090122
- Expiration date of the lot/batch: December 1, 1991
- Stability under test conditions: Stable
- Storage condition of test material: In the original container at room temperature in the dark
- Other:

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Remarks on exposure duration:

NOT_SPECIFIED

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

RANGE-FINDING TEST

I n the range finding no significant immobility of daphnia was seen at all concentrations tested. However, the mobility of all daphnia exposed to 1000 mg/l had decreased i n comparison with the controls.

FINAL STUDY: IMMOBILITY

After 48 hours o f exposure no significant immobility of daphnia was seen at all concentrations tested.

FINAL STUDY: EXPERIMENTAL CONDITIONS

The pH varied from 6.3 to 8.4.

Oxygen concentration in the test media was found to be > 5 mg/l for a1l measurements.

The temperature of the test medium measured i n the blank control varied from l 9 to 20.5 ° C.

FINAL STUDY: ACCEPTABILITY OF THE TEST

In the controls not more than 10% o f the daphnia became immobilized or

trapped at the surface of the water .

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Under the conditions o f the present study . DC 5067 appeared to be nontoxic to Daphnia magna, i . e . the 4 8 h-EC50 w ith respect t o mobiiity was
> nominally 1000 mg/l .

Executive summary:

Daphnia were exposed for a maximum of 48 hours to a concentration range of 100 to 1000 mg/l forming a geometric progression with a factor of 1.8. The test was performed in duplicate with 10 daphnia per vessel. After 48 hours of exposure no significant immobility of daphnia was seen at a11 concentrations tested.

Under conditions of the present sutdy, DC 5067 appeared to be non-toxic to Daphnia magna, i . e . , the 48h-EC50 with respect to mobility was > nominally 1000 mg/l .