Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 April, 1991
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Study
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Identification: DC 5067
Description: Clear, light brown liquid
Lot Number: AB 090122
Purity: >99%
Storage conditions: In the original container at room temperature in the dark
Stability under storage conditions: Stab1e
Expiry date: December 1, 1991

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
ca. 1 400
Temp.:
20 °C
pH:
>= 6 - <= 8
Type:
Pow
Partition coefficient:
ca. 4 000 000
Temp.:
20 °C
pH:
>= 6 - <= 8

Applicant's summary and conclusion

Conclusions:
The partition coefficient (Pow) of DC 5067 was estimated to be 1.4 x l0exp3 (log Pow=3. 1) and 4.0 x l0exp6 (log Pow < 6.6).
Executive summary:

DC 5067 appeared to be a surface active substance (see RCC NOTOX report 048678) "Determination of the surface tension of DC 5067". The HPLC method as well as the flask-shaking method (see OECD guideline no. 107 and EEC directive L251) for the determination of the partition coefficient applies only to pure substances which are not surface active, therefore the main study was not performed. During the preliminary test, the partition coefficient (Pow) of DC 5067 was estimated to be between 1.4 x l03 (log Pow=3.1) and 4.0 x l06 (log Pow 6.6), as a quotient of the maximum solubility of the test substance in n-octanol and water.