Registration Dossier
Registration Dossier
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EC number: 424-190-3 | CAS number: 105641-66-5 DIAZO ER 1273
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 14 August 1992 to 3 September 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 1989
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2.6
- Temp.:
- 39 °C
- pH:
- 4.7
- Remarks on result:
- other: by-products
- Type:
- log Pow
- Partition coefficient:
- 4
- Temp.:
- 39 °C
- pH:
- 4.7
- Remarks on result:
- other: main component
- Conclusions:
- The log Pow of the test item was determined using the HPLC method. For the main component, a log Pow of 4 was determined. The log Pow of the by-products was determined to be 2.6.
- Executive summary:
The log Pow of the test item was determined using the HPLC method, according to OECD Guideline 117. For the main component, a log Pow of 4 was determined. The log Pow of the by-products was determined to be 2.6.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 24, 2019 to February 14, 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EU method A.24. Partition coefficient n-octan ol/water
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Storage conditions: Refrigerator (2"C to I'C)
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.7
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- Preliminary visual estimation of the n-octanol solubility
According to a preliminary test the solubility of the test item in n-octanolwas below 14 mg/L by visual judgement. - Conclusions:
- The partition coefficient n-octanol/water of the test item was determined according to the HPLC method. The log Pow was calculated to be: log Pow = 2.7.
- Executive summary:
The partition coefficient n-octanol/water of the test item was determined according to the HPLC method (OECD 117). The weighted average log Pow was calculated to be: log Pow = 2.7.
Referenceopen allclose all
Description of key information
The partition coefficient n-octanol/water of the test item was determined according to the HPLC method (OECD 117). The weighted average log Pow was calculated to be: log Pow = 2.7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.7
- at the temperature of:
- 25 °C
Additional information
In the key study, the log Pow of the test substance was determined to be 2.7 (reference 4.7-1). In the supporting study (reference 4.7-2, two log Pow values for the main component (log Pow=4) and the by-products (log Pow=2.6) were determined. This study was considered as supporting information.
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