Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Automatic calculation with MeClas tool
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity potential of the UVCB substance was determined by classifying based on the Mixture rules from EU CLP (additivity formula of classified components to derive hazard class) and back calculation to the corresponding acute toxicity range estimate.
- GLP compliance:
- no
- Remarks:
- other quality assurance was applied
Test material
- Reference substance name:
- aluminium, magnesium and silicon oxides and hydroxides from refinement of aluminium salt slag residues
- Molecular formula:
- UVCB
- IUPAC Name:
- aluminium, magnesium and silicon oxides and hydroxides from refinement of aluminium salt slag residues
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- other: acute toxicity estimate ATE
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: prediction
Any other information on results incl. tables
According to MeClas, the substance is not classified as Acute toxicity Dermal under CLP.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Good quality, conservative estimate of the Acute Dermal Toxicity Estimate of the UVCB substance.
The substance is not classified as acute toxic - dermal. - Executive summary:
The study provided a conservative estimate, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case substance representative.
Validity of the model used:
- Defined endpoint: the endpoint is a REACH compliant defined endpoint
- Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria
- Applicability domain: applicable to classify complex metal containing materials.
- Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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