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EC number: 279-903-9 | CAS number: 82136-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 August 1980 (started); 30 September 1980 (reported)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study report provides basic data, but some details missing including duration of treatment, individual animal data and scoring system
Data source
Reference
- Reference Type:
- other: research report
- Title:
- Unnamed
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- In general the techniques of tests as published by the FDA of the United States (Fed. Reg. 28 (119), 5582, 1963) and Draize and Kelley (Drug Cosmet. Industr. 71: 36, 1952) were followed.
- GLP compliance:
- no
- Remarks:
- study was conducted before implementation of GLP
Test material
- Reference substance name:
- 2-[[3-(dimethylamino)propyl]methylamino]ethanol
- EC Number:
- 279-903-9
- EC Name:
- 2-[[3-(dimethylamino)propyl]methylamino]ethanol
- Cas Number:
- 82136-26-3
- Molecular formula:
- C8H20N2O
- IUPAC Name:
- 2-{[3-(dimethylamino)propyl](methyl)amino}ethan-1-ol
- Details on test material:
- - Name of test compound: ABBOTT-51806
- Lot No. 7753-37
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- weight at study initiation: 2.82 kg (mean)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL/animal
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 30 days
- Number of animals or in vitro replicates:
- 9 males, half of which had their eyes rinsed with water (20-30s) after treatment
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corneal opacity
- Basis:
- mean
- Reversibility:
- other: washed eye: reversible within 30 days; unwashed eye: reversible within 22 days
- Remarks on result:
- other: moderate corneal opacity in all animals (no difference between unwashed and washed eye)
- Irritation parameter:
- other: iritis
- Basis:
- mean
- Reversibility:
- other: washed eye: reversible within 30 days; unwashed eye: reversible within 22 days
- Remarks on result:
- other: slight to moderate iritis in all animals (no difference between unwashed and washed eye)
- Irritation parameter:
- other: conjunctivitis
- Basis:
- mean
- Reversibility:
- other: washed eye: reversible within 7 days; unwashed eye: reversible within 8 days
- Remarks on result:
- other: moderate conjunctivitis in all animals (no difference between unwashed and washed eye)
- Irritation parameter:
- other: chemosis
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: moderate chemosis in all animals (no difference between unwashed and washed eye)
- Irritation parameter:
- other: discharge
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: discharge in all animals (no difference between unwashed and washed eye)
- Irritant / corrosive response data:
- scores (including the reversibility of the effects observed) for individual animals: not available
Applicant's summary and conclusion
- Interpretation of results:
- other: interpretation of results not possible (due to limited documentation), but also not necessary as the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
- Conclusions:
- Signs of ocular irritation were observed after test substance administration, i.e.
- corneal opacity (reversible within 30 days for washed eye, within 22 days for unwashed eye),
- iritis (reversible within 30 days for washed eye, within 22 days for unwashed eye),
- conjunctival redness (reversible within 7 days for washed eye, within 8 days for unwashed eye),
- chemosis and
- discharge. - Executive summary:
The substance 2-[[3-(dimethylamino)propyl]methylamino]ethanol was tested in a primary ocular irritation study comparable to OECD guideline 405 (prior to introduction of GLP).
Nine male New Zealand White rabbits were used; for 3 animals substance was washed out after 20-30 seconds, whereas for the remaining animals eyes were not washed.
Signs of ocular irritation were observed after test substance administration, i.e. corneal opacity (reversible within 30 days for washed eye, within 22 days for unwashed eye), iritis (reversible within 30 days for washed eye, within 22 days for unwashed eye), conjunctival redness (reversible within 7 days for washed eye, within 8 days for unwashed eye), chemosis and discharge.
In conclusion, undiluted 2-[[3-(dimethylamino)propyl]methylamino]ethanol caused severe irritation when instilled directly into the eyes of rabbits.
The presented experimental data would not be sufficient to classify the substance, but this is not necessary as the substance is classified as skin corrosive (sub-category 1B; H314); such a substance is automatically considered to be severely damaging to the eye and is classified but not labelled for serious eye damage in addition to skin corrosion.
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