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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 September 1980 (started); 22 September 1980 (reported)
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study report provides basic data, but some details missing including dose levels

Data source

Reference
Reference Type:
other: research report
Title:
Unnamed
Report date:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
Principles of method if other than guideline:
The test substance was administered to groups of male and female rats by oral gavage and observed for a period of 14 days.
GLP compliance:
no
Remarks:
study was conducted before implementation of GLP
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[[3-(dimethylamino)propyl]methylamino]ethanol
EC Number:
279-903-9
EC Name:
2-[[3-(dimethylamino)propyl]methylamino]ethanol
Cas Number:
82136-26-3
Molecular formula:
C8H20N2O
IUPAC Name:
2-{[3-(dimethylamino)propyl](methyl)amino}ethan-1-ol
Details on test material:
- Name of test compound: ABBOTT-51806
- Lot No. 7753-37

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Doses:
1.59 mL/kg bw, 2.52 mL/kg bw and 4.00 mL/kg bw [not documented; dose volume was calculated as dose level (g/kg) / density (g/mL)]
No. of animals per sex per dose:
3 (not documented)
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1.7 mL/kg bw
Based on:
test mat.
95% CL:
1.47 - 1.95
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
1 537 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
1.74 mL/kg bw
Based on:
test mat.
95% CL:
1.52 - 1.99
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
1 573 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
- LD50 (male rat): 1573 mg/kg bw;
- LD50 (female rat): 1537 mg/kg bw
Executive summary:

The test item 2-[[3-(dimethylamino)propyl]methylamino]ethanol was tested in an acute oral toxicity study [equivalent or similar to OECD Guideline 401 (deleted on 17 Dec. 2002), prior to introduction of GLP].


Three female and three male rats per dose level were gavaged once with the test item at dose levels of about 1.6 mL/kg bw, 2.5 mL/kg bw and 4.0 mL/kg bw (number of animals and doses not documented in report).


The acute oral median lethal dose (LD50) of the test material in the rat was estimated to be 1573 mg/kg bw for male and 1537 mg/kg bw for female rat.


Using the EU Globally Harmonised System (GHS), the substance needs to be classified as Acute tox. 4, H302.