Registration Dossier
Registration Dossier
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EC number: 204-634-0 | CAS number: 123-54-6
Endpoint summary
Administrative data
Description of key information
2,4-Pentanedione was not irritating to the skin or the eyes of rabbits.
Key value for chemical safety assessment
Additional information
Skin irritation:
In the key study for skin irritation, 0.5 mL undiluted 2,4-pentanedione was applied to the clipped, intact dorsal skin of 6 New Zealand White rabbits (3 males and 3 females) under a gauze patch and was loosely covered with impervious sheeting (BRRC48 -34, 1985). Skin reaction was scored by the method of Draize at 1 hour and 1, 2, 3, 7 and 14 days after removal of the dressing. Mean scores of all 6 animals (24, 48, 72 h) for erythema and edema was 0.8 and 0.4, respectively. After 7 days no erythema and edema reactions have been observed. Slight desquamation was observed in 5/6 animals after 7 days, but was also fully reversible within 14 days.
Eye irritation:
Eye irritation was observed in 6 New Zealand White rabbits, which were instilled 0.1 mL of the test substance (BRRC48 -34, 1985). No washing was performed and the eyes were observed for 7 days. Slight redness or chemosis was observed in the eyes of single animals after 1 and 4 h, respectively. No effects have been observed during the 24, 48, 72 h period or later in any animals.
In conclusion, 2,4 -pentanedione showed no potential for irritation to the skin or to the eyes.
Respiratory irritation:
There exists no standard test method for the assessment of respiratory irritation. Thus, findings for skin/eye irritation, inhalation toxicity and sensitisation are reviewed. Slight reactions on the skin and the eyes were observed in skin/eye irritation studies, especially at early time points. No reliable data are available from sensitization studies. In acute, subacute and subchronic inhalation toxicity studies wetness, inflammation and partly necrosis of the nasal mucosa was reported. No lesions in the lower respiratory tract (trachea and lung) were reported. Thus, based on the data available, respiratory irritation cannot be excluded, but is unlikely to happen in the lower respiratory tract.
Justification for classification or non-classification
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