Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 416-530-4 | CAS number: 178949-82-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-04-23 to 1993-06-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -4.7
- Temp.:
- 20 °C
- pH:
- 7
- Conclusions:
- In a preliminary GLP study conducted according to OECD Guideline 107 (shake-flask method), the log Pow (n-octanol/water partition coefficient) for trisodium EDDS was estimated to be <-4.7
- Executive summary:
In a preliminary GLP study conducted according to OECD Guideline 107 (shake-flask method), the partition coefficient (n-octanol/water) for trisodium EDDS was estimated to be < 2 x 10-5 (log Pow <-4.7) at 20°C.
Reference
No main study performed as calculated log Pow < -4.0
Description of key information
In a preliminary GLP study conducted according to OECD Guideline 107 (shake-flask method), the log Pow (n-octanol/water partition coefficient) for trisodium EDDS was estimated to be <-4.7 at 20°C
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -4.7
- at the temperature of:
- 20 °C
Additional information
In a preliminary GLP study conducted according to OECD Guideline 107 (shake-flask method), the partition coefficient (n-octanol/water) for trisodium EDDS was estimated to be < 2 x 10-5(log Pow <-4.7) at 20oC (de Vries, 1993a).
In addition, in a GLP study conducted according to OECD Guideline 107 and EU Method A.8 (the shake-flask method), the log Pow (n-octanol/water partition co-efficient) for EDDS acid was estimated to be <-1.4 at 23oC (Gair et al. 2002).
[Data on EDDS free acid is considered relevant to use for understanding the partition coefficient of trisodium EDDS, and is acceptable for using as read-across information.]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
